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CYP2E1 Substrate Inhibition: MECHANISTIC INTERPRETATION THROUGH AN EFFECTOR SITE FOR MONOCYCLIC COMPOUNDS()
In this study we offer a mechanistic interpretation of the previously known but unexplained substrate inhibition observed for CYP2E1. At low substrate concentrations, p-nitrophenol (pNP) was rapidly turned over (47 min(−1)) with relatively low K(m) (24 μM); nevertheless, at concentrations of >100...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3933162/ https://ncbi.nlm.nih.gov/pubmed/18056994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707630200 |
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