Mice with targeted disruption of spermidine/spermine N(1)-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

The N(1)-acetylation of spermidine or spermine by spermidine/spermine N(1)-acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine catabolism. We have now generated SSAT knockout (SSAT-KO) mice, which confirmed our earlier results with SSAT deficient embryonic stem (ES) cells...

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Autors principals: Niiranen, Kirsi, Keinänen, Tuomo A, Pirinen, Eija, Heikkinen, Sami, Tusa, Maija, Fatrai, Szabolcs, Suppola, Suvikki, Pietilä, Marko, Uimari, Anne, Laakso, Markku, Alhonen, Leena, Jänne, Juhani
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2006
Matèries:
Epigenetic Review Series
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933077/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2755/jcmm010.004.02
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