Glycoengineering of Therapeutic Antibodies Enhances Monocyte/Macrophage-Mediated Phagocytosis and Cytotoxicity

Therapeutic Abs possess several clinically relevant mechanisms of action including perturbation of tumor cell signaling, activation of complement-dependent cytotoxicity, Ab-dependent cellular cytotoxicity (ADCC), Ab-dependent cellular phagocytosis (ADCP), and induction of adaptive immunity. In view...

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Bibliografiske detaljer
Main Authors: Herter, Sylvia, Birk, Martina C., Klein, Christian, Gerdes, Christian, Umana, Pablo, Bacac, Marina
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2014
Fag:
Immunotherapy and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932809/
https://ncbi.nlm.nih.gov/pubmed/24489098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301249
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