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The Sensitive Balance Between the Fully Folded and Locally Unfolded Conformations of a Model Peroxiredoxin()

To reduce peroxides, peroxiredoxins (Prx) require a key ‘peroxidatic’ cysteine, that in a substrate-ready fully folded (FF) conformation becomes oxidized to sulfenic acid, and then after a local unfolding (LU) of the active site, forms a disulfide bond with a second ‘resolving’ Cys. For Salmonella t...

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Main Authors: Perkins, Arden, Nelson, Kimberly J., Williams, Jared R., Parsonage, Derek, Poole, Leslie B., Karplus, P. Andrew
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932808/
https://ncbi.nlm.nih.gov/pubmed/24175952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4011573
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