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Targeting Protein Kinase CK2 Suppresses Pro-survival Signaling Pathways and Growth of Glioblastoma

PURPOSE: Gliomas are the most frequently occurring primary malignancies in the brain, and glioblastoma (GBM) is the most aggressive of these tumors. Protein kinase CK2 is composed of two catalytic subunits (α and/or α’) and two β regulatory subunits. CK2 suppresses apoptosis, promotes neo-angiogenes...

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Bibliografski detalji
Glavni autori: Zheng, Ying, McFarland, Braden C., Drygin, Denis, Yu, Hao, Bellis, Susan L., Kim, Hyunsoo, Bredel, Markus, Benveniste, Etty N.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932633/
https://ncbi.nlm.nih.gov/pubmed/24036851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0265
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