The hard-soft acid-base principle in enzymatic catalysis: dual reactivity of phosphoenolpyruvate.
In this paper, the chemical reactivity of C3 of phosphoenolpyruvate (PEP) has been analyzed in terms of density functional theory quantified through quantum chemistry calculations. PEP is involved in a number of important enzymatic reactions, in which its C3 atom behaves like a base. In three differ...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1996
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39326/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643451/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.10.4612 |
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