Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen.

Choleragen and its A protomer catalyzed the hydrolysis of NAD to ADP-ribose and nicotinamide. NADase activity was inhibited by gangliosides GM1 (galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide), GM2 (N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylcera...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Moss, J, Osborne, J C, Fishman, P H, Brewer, H B, Vaughan, M, Brady, R O
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1977
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393199/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/13371/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.1.74
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