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TALEN-Mediated Modification of the Bovine Genome for Large-Scale Production of Human Serum Albumin
As an initial step towards creating genetically modified cattle as a biopharming source of recombinant human serum albumin (rHSA), we report modification of the bovine albumin (bA) locus by transcription activator-like effector nuclease (TALEN)-stimulated homology-directed repair (HDR). Pedigreed bo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931800/ https://ncbi.nlm.nih.gov/pubmed/24586924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089631 |
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