Tissue Kallikrein Mediates Pro-Inflammatory Pathways and Activation of Protease-Activated Receptor-4 in Proximal Tubular Epithelial Cells

Tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose (HG) in human proximal tubular epithelial cells (PTEC). Since the kallikrein-kinin system (KKS) has been linked to cellular inflammatory process in many diseases, it is likely that KLK1 ex...

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Detalhes bibliográficos
Main Authors: Yiu, Wai Han, Wong, Dickson W. L., Chan, Loretta Y. Y., Leung, Joseph C. K., Chan, Kwok Wah, Lan, Hui Yao, Lai, Kar Neng, Tang, Sydney C. W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931644/
https://ncbi.nlm.nih.gov/pubmed/24586431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088894
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