β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

Wolfram syndrome is an autosomal recessive disorder caused by mutations in WFS1 and is characterized by insulin-dependent diabetes mellitus, optic atrophy, and deafness. To investigate the cause of β-cell failure, we used induced pluripotent stem cells to create insulin-producing cells from individu...

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Bibliographic Details
Main Authors:	Shang, Linshan, Hua, Haiqing, Foo, Kylie, Martinez, Hector, Watanabe, Kazuhisa, Zimmer, Matthew, Kahler, David J., Freeby, Matthew, Chung, Wendy, LeDuc, Charles, Goland, Robin, Leibel, Rudolph L., Egli, Dieter
Format:	Artigo
Language:	Inglês
Published:	American Diabetes Association 2014
Subjects:	Metabolism
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3931392/ https://ncbi.nlm.nih.gov/pubmed/24227685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0717
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β-Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

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