Gerstmann-Sträussler-Scheinker Disease and “Anchorless Prion Protein” Mice Share Prion Conformational Properties Diverging from Sporadic Creutzfeldt-Jakob Disease

The role of the GPI-anchor in prion disease pathogenesis is still a challenging issue. In vitro studies have shown that anchorless cellular prion protein (PrP(C)) undergoes aberrant post-translational processing and metabolism. Moreover, transgenic (Tg) mice overexpressing anchorless PrP(C) develop...

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Detalhes bibliográficos
Main Authors: Zanusso, Gianluigi, Fiorini, Michele, Ferrari, Sergio, Meade-White, Kimberly, Barbieri, Ilaria, Brocchi, Emiliana, Ghetti, Bernardino, Monaco, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931049/
https://ncbi.nlm.nih.gov/pubmed/24398683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.531335
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