Loss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin

The Grainyhead-like 1 (GRHL1) transcription factor regulates the expression of desmosomal cadherin desmoglein 1 (Dsg1) in suprabasal layers of the epidermis. As a consequence, the epidermis of Grhl1-null mice displays fewer desmosomes that are abnormal in structure. These mice also exhibit mild chro...

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Bibliographic Details
Main Authors: Mlacki, Michal, Darido, Charbel, Jane, Stephen M., Wilanowski, Tomasz
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930704/
https://ncbi.nlm.nih.gov/pubmed/24586629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089247
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