Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

Mosquito-borne chikungunya virus (CHIKV) is a positive-sense, single-stranded RNA virus from the genus Alphavirus, family Togaviridae, which causes fever, rash and severe persistent polyarthralgia in humans. Since there are currently no FDA licensed vaccines or antiviral therapies for CHIKV, the dev...

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Bibliographische Detailangaben
Hauptverfasser: Gardner, Christina L., Hritz, Jozef, Sun, Chengqun, Vanlandingham, Dana L., Song, Timothy Y., Ghedin, Elodie, Higgs, Stephen, Klimstra, William B., Ryman, Kate D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930508/
https://ncbi.nlm.nih.gov/pubmed/24587470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002719
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