Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa

Extreme differences in allele frequency between West Africans and Eurasians were observed for a leucine-to-valine substitution (Leu372Val) in the human intestinal zinc uptake transporter, ZIP4, yet no further evidence was found for a selective sweep around the ZIP4 gene (SLC39A4). By interrogating a...

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Main Authors: Engelken, Johannes, Carnero-Montoro, Elena, Pybus, Marc, Andrews, Glen K., Lalueza-Fox, Carles, Comas, David, Sekler, Israel, de la Rasilla, Marco, Rosas, Antonio, Stoneking, Mark, Valverde, Miguel A., Vicente, Rubén, Bosch, Elena
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930504/
https://ncbi.nlm.nih.gov/pubmed/24586184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004128
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