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Adenosine receptors as drug targets — what are the challenges?

Adenosine signalling has long been a target for drug development, with adenosine itself or its derivatives being used clinically since the 1940s. In addition, methylxanthines such as caffeine have profound biological effects as antagonists at adenosine receptors. Moreover, drugs such as dipyridamole...

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Hlavní autoři: Chen, Jiang-Fan, Eltzschig, Holger K., Fredholm, Bertil B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930074/
https://ncbi.nlm.nih.gov/pubmed/23535933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd3955
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