Bilirubin Increases Insulin Sensitivity in Leptin-Receptor Deficient and Diet-Induced Obese Mice Through Suppression of ER Stress and Chronic Inflammation

Obesity-induced endoplasmic reticulum (ER) stress causes chronic inflammation in adipose tissue and steatosis in the liver, and eventually leads to insulin resistance and type 2 diabetes (T2D). The goal of this study was to understand the mechanisms by which administration of bilirubin, a powerful a...

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Main Authors: Dong, Huansheng, Huang, Hu, Yun, Xinxu, Kim, Do-sung, Yue, Yinan, Wu, Hongju, Sutter, Alton, Chavin, Kenneth D., Otterbein, Leo E., Adams, David B., Kim, Young-Bum, Wang, Hongjun
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2014
Assuntos:
Energy Balance-Obesity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929745/
https://ncbi.nlm.nih.gov/pubmed/24424052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1667
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