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Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes.

The function of the gamma-glutamyl cycle was explored in in vivo studies in which amino acids and specific inhibitors of cycle enzymes (gamma-glutamyl transpeptidase, gamma-glutamyl cyclotransferase, gamma-glutamylcysteine synthetase, and 5-oxoprolinase) were administered to mice. The findings, whic...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Griffith, O W, Bridges, R J, Meister, A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1978
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392972/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/31622/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.11.5405
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