Pulvomycin, an inhibitor of protein biosynthesis preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA.

Pulvomycin and the synonymous antibiotics labilomycin and 1063-Z are shown to inhibit prokaryotic protein synthesis by acting on elongation factor Tu (EF-Tu): in the presence of the antibiotic, the affinity of EF-Tu for guanine nucleotides is altered, the EF-Tu.GDP/GTP exchange is catalyzed, and the...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Wolf, H, Assmann, D, Fischer, E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1978
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392955/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/364475/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.11.5324
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