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Single-molecule FRET supports the two-state model of Argonaute action

Argonaute can be found in all three domains of life and is the functional core of the eukaryotic RNA-silencing machinery. In order to shed light on the conformational changes that drive Argonaute action, we performed single-molecule FRET measurements employing a so far uncharacterized member of the...

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Détails bibliographiques
Auteurs principaux: Zander, Adrian, Holzmeister, Phil, Klose, Daniel, Tinnefeld, Philip, Grohmann, Dina
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929424/
https://ncbi.nlm.nih.gov/pubmed/24442234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.27446
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