Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralizing Antibodies in Multiple Sclerosis Patients Treated with Interferon-Beta

BACKGROUND: Anti interferon-beta (IFN-β) neutralizing antibodies (NAb) affect efficacy of treatment of multiple sclerosis patients, but exactly when the detrimental effects of NAbs offset therapeutic efficacy is debated. Quantification of intracellular pathway-specific phosphorylation by phospho-spe...

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Detalhes bibliográficos
Main Authors: Gavasso, Sonia, Mosleth, Ellen Faergestad, Marøy, Tove, Jørgensen, Katarina, Nakkestad, Hanne-Linda, Gjertsen, Bjørn-Tore, Myhr, Kjell-Morten, Vedeler, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929401/
https://ncbi.nlm.nih.gov/pubmed/24586361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088632
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