Magic Angle Spinning NMR Reveals Sequence-Dependent Structural Plasticity, Dynamics, and the Spacer Peptide 1 Conformation in HIV-1 Capsid Protein Assemblies

A key stage in HIV-1 maturation towards an infectious virion requires sequential proteolytic cleavage of the Gag polyprotein leading to the formation of a conical capsid core that encloses the viral RNA genome and a small complement of proteins. The final step of this process involves severing the S...

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Autores principales: Han, Yun, Hou, Guangjin, Suiter, Christopher L., Ahn, Jinwoo, Byeon, In-Ja L., Lipton, Andrew S., Burton, Sarah, Hung, Ivan, Gor’kov, Peter L., Gan, Zhehong, Brey, William, Rice, David, Gronenborn, Angela M., Polenova, Tatyana
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928671/
https://ncbi.nlm.nih.gov/pubmed/24164646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja406907h
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