Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo.

Dopamine (DA) deficiency has been implicated in Lesch-Nyhan disease (LND), a genetic disorder that is characterized by hyperuricemia, choreoathetosis, dystonia, and compulsive self-injury. To establish that DA deficiency is present in LND, the ligand WIN-35,428, which binds to DA transporters, was u...

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Main Authors: Wong, D F, Harris, J C, Naidu, S, Yokoi, F, Marenco, S, Dannals, R F, Ravert, H T, Yaster, M, Evans, A, Rousset, O, Bryan, R N, Gjedde, A, Kuhar, M J, Breese, G R
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC39282/
https://ncbi.nlm.nih.gov/pubmed/8643611
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