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HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways
HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expr...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3928010/ https://ncbi.nlm.nih.gov/pubmed/23916472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.07.028 |
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