Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss

BACKGROUND: The resistance of cancerous cells to chemotherapy remains the main limitation for cancer treatment at present. Doxorubicin (DOX) is a potent antitumor drug that activates the ubiquitin-proteasome system, but unfortunately it also activates the Nuclear factor kappa B (NF-кB) pathway leadi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ortiz-Lazareno, Pablo César, Bravo-Cuellar, Alejandro, Lerma-Díaz, José Manuel, Jave-Suárez, Luis Felipe, Aguilar-Lemarroy, Adriana, Domínguez-Rodríguez, Jorge Ramiro, González-Ramella, Oscar, De Célis, Ruth, Gómez-Lomelí, Paulina, Hernández-Flores, Georgina
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2014
Gaiak:
Primary Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927225/
https://ncbi.nlm.nih.gov/pubmed/24495648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-14-13
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