TNF-α induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-κB activation in osteoblast-like MC3T3-E1 cells

BACKGROUND: Matrix metalloproteinase-9 (MMP-9) has been shown to be induced by cytokines including TNF-α and may contribute to bone inflammatory diseases. However, the mechanisms underlying MMP-9 expression induced by TNF-α in MC3T3-E1 cells remain unclear. RESULTS: We applied gelatin zymography, We...

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Bibliographic Details
Main Authors: Tsai, Chia-Lan, Chen, Wei-Chung, Hsieh, Hsi-Lung, Chi, Pei-Ling, Hsiao, Li-Der, Yang, Chuen-Mao
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926355/
https://ncbi.nlm.nih.gov/pubmed/24502696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-21-12
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