Targeted disruption of the mZP3 gene results in production of eggs lacking a zona pellucida and infertility in female mice.

Mammalian eggs are surrounded by a thick extracellular coat, the zona pellucida, that plays important roles during early development. The mouse egg zona pellucida is constructed of three glycoproteins, called mZP1, mZP2, and mZP3. The gene encoding mZP3 is expressed only by growing oocytes during a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Liu, C, Litscher, E S, Mortillo, S, Sakai, Y, Kinloch, R A, Stewart, C L, Wassarman, P M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39263/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643592/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.11.5431
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