Phase I study of azacitidine and bortezomib in adults with relapsed or refractory acute myeloid leukemia

We previously reported that bortezomib indirectly modulates transcription of DNA methyltransferase 1 (DNMT). We designed a phase I study of azacitidine (a direct DNMT inhibitor) plus bortezomib in acute myeloid leukemia (AML) to determine safety and tolerability. Twenty-three adults with relapsed/re...

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Detalhes bibliográficos
Main Authors: Walker, Alison R., Klisovic, Rebecca B., Garzon, Ramiro, Schaaf, Larry J., Humphries, Kristina, Devine, Steven M., Byrd, John C., Grever, Michael R., Marcucci, Guido, Blum, William
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925754/
https://ncbi.nlm.nih.gov/pubmed/23952243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2013.833333
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