A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling

Osteosarcoma is the most common primary bone tumor in children and adolescents. There is a critical need to find more potent drugs for patients with metastatic or recurrent disease. Berbamine (BBM) is a natural compound derived from the Berberis amurensis plants. BBM and its derivatives have been sh...

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Main Authors: Yang, Fan, Nam, Sangkil, Zhao, Robin, Tian, Yan, Liu, Lucy, Horne, David A, Jove, Richard
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2013
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925657/
https://ncbi.nlm.nih.gov/pubmed/24025361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26045
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