Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis

BACKGROUND: Cigarette smoking causes Chronic Obstructive Pulmonary Disease (COPD), the 3rd leading cause of death in the U.S. CFTR ion transport dysfunction has been implicated in COPD pathogenesis, and is associated with chronic bronchitis. However, susceptibility to smoke induced lung injury is va...

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Hlavní autoři: Raju, S Vamsee, Tate, Jody H, Peacock, Sandra KG, Fang, Ping, Oster, Robert A, Dransfield, Mark T, Rowe, Steven M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925354/
https://ncbi.nlm.nih.gov/pubmed/24517344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-18
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