Disruption of the aldolase A tetramer into catalytically active monomers.
The fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) homotetramer has been destabilized by site-directed mutagenesis at the two different subunit interfaces. A double mutant aldolase, Q125D/E224A, sediments as two distinct species, characteristic of a slow equilibrium, with velocities expected for t...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39253/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643582/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.11.5374 |
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