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Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer

BACKGROUND: Esterases are often overexpressed in cancer cells and can have chiral specificities different from that of the corresponding normal tissues. For this reason, ester prodrugs could be a promising approach in chemotherapy. In this study, we focused on the identification and characterization...

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Autors principals: McGoldrick, Christopher A, Jiang, Yu-Lin, Paromov, Victor, Brannon, Marianne, Krishnan, Koyamangalath, Stone, William L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925015/
https://ncbi.nlm.nih.gov/pubmed/24512522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-77
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