Direct C-1 hydroxylation of vitamin D compounds: convenient preparation of 1alpha-hydroxyvitamin D3, 1alpha, 25-dihydroxyvitamin D3, and 1alpha-hydroxyvitamin D2.

An efficient procedure for the direct C-1 hydroxylation of vitamin D compounds has been developed. The method involves conversion of vitamin D3 tosylates to 3,5-cyclovitamin D derivatives, allylic oxidation with selenium dioxide, and acid-catalyzed solvolysis to the 1 alpha-hydroxyvitamin D analogs....

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Bibliographic Details
Main Authors: Paaren, H E, Hamer, D E, Schnoes, H K, DeLuca, H F
Format: Artigo
Language:Inglês
Published: 1978
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC392492/
https://ncbi.nlm.nih.gov/pubmed/209448
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