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Mutagenesis during in vitro DNA synthesis.

The error frequency of in vitro DNA synthesis using a natural DNA template has been measured with a biological assay for nucleotide substitutions. phiX174 DNA containing an amber mutation was copied in vitro by Escherichia coli DNA polymerase I, and the reversion frequency of the progeny DNA was det...

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Bibliografiske detaljer
Main Authors: Weymouth, L A, Loeb, L A
Format: Artigo
Sprog:Inglês
Udgivet: 1978
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC392454/
https://ncbi.nlm.nih.gov/pubmed/347450
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