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Simvastatin Treatment Highlights a New Role for the Isoprenoid/Cholesterol Biosynthetic Pathway in the Modulation of Emotional Reactivity and Cognitive Performance in Rats

The aim of the present work was to shed light on the role played by the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and memory consolidation in rodents through the inhibition of the key and rate-limiting enzyme 3-hydroxy 3-methylglutaryl Coenzyme A reductase...

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Detalhes bibliográficos
Main Authors: Segatto, Marco, Manduca, Antonia, Lecis, Claudio, Rosso, Pamela, Jozwiak, Adam, Swiezewska, Ewa, Moreno, Sandra, Trezza, Viviana, Pallottini, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924519/
https://ncbi.nlm.nih.gov/pubmed/24108067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.284
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