A Functional, Genome-wide Evaluation of Liposensitive Yeast Identifies the “ARE2 Required for Viability” (ARV1) Gene Product as a Major Component of Eukaryotic Fatty Acid Resistance

The toxic subcellular accumulation of lipids predisposes several human metabolic syndromes, including obesity, type 2 diabetes, and some forms of neurodegeneration. To identify pathways that prevent lipid-induced cell death, we performed a genome-wide fatty acid sensitivity screen in Saccharomyces c...

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Detalhes bibliográficos
Main Authors: Ruggles, Kelly V., Garbarino, Jeanne, Liu, Ying, Moon, James, Schneider, Kerry, Henneberry, Annette, Billheimer, Jeff, Millar, John S., Marchadier, Dawn, Valasek, Mark A., Joblin-Mills, Aidan, Gulati, Sonia, Munkacsi, Andrew B., Repa, Joyce J., Rader, Dan, Sturley, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924304/
https://ncbi.nlm.nih.gov/pubmed/24273168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515197
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