A Mechanism for Actin Filament Severing by Malaria Parasite Actin Depolymerizing Factor 1 via a Low Affinity Binding Interface

Actin depolymerizing factor (ADF)/cofilins are essential regulators of actin turnover in eukaryotic cells. These multifunctional proteins facilitate both stabilization and severing of filamentous (F)-actin in a concentration-dependent manner. At high concentrations ADF/cofilins bind stably to F-acti...

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Detalhes bibliográficos
Main Authors: Wong, Wilson, Webb, Andrew I., Olshina, Maya A., Infusini, Giuseppe, Tan, Yan Hong, Hanssen, Eric, Catimel, Bruno, Suarez, Cristian, Condron, Melanie, Angrisano, Fiona, NebI, Thomas, Kovar, David R., Baum, Jake
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924271/
https://ncbi.nlm.nih.gov/pubmed/24371134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523365
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