Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration

The Spt–Ada–Gcn5–acetyltransferase (SAGA) chromatin-modifying complex possesses acetyltransferase and deubiquitinase activities. Within this modular complex, Ataxin-7 anchors the deubiquitinase activity to the larger complex. Here we identified and characterized Drosophila Ataxin-7 and found that re...

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Hauptverfasser: Mohan, Ryan D., Dialynas, George, Weake, Vikki M., Liu, Jianqi, Martin-Brown, Skylar, Florens, Laurence, Washburn, Michael P., Workman, Jerry L., Abmayr, Susan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923968/
https://ncbi.nlm.nih.gov/pubmed/24493646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.225151.113
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