The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis

MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-sensitive microRNAs in atherosclerosis is still unclear. Here we identify miRNA-712 (miR-712) as a mechanosensitive miRNA upregulated by disturbed flow (d-flow) in endothelial cells, in vitro and in vivo. We also sh...

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Autors principals: Son, Dong Ju, Kumar, Sandeep, Takabe, Wakako, Kim, Chan Woo, Ni, Chih-Wen, Alberts-Grill, Noah, Jang, In-Hwan, Kim, Sangok, Kim, Wankyu, Kang, Sang Won, Baker, Andrew H., Seo, Jai Woong, Ferrara, Katherine W., Jo, Hanjoong
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923891/
https://ncbi.nlm.nih.gov/pubmed/24346612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4000
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