A novel human aquaporin-4 splice variant exhibits a dominant-negative activity: a new mechanism to regulate water permeability

Two major isoforms of aquaporin-4 (AQP4) have been described in human tissue. Here we report the identification and functional analysis of an alternatively spliced transcript of human AQP4, AQP4-Δ4, that lacks exon 4. In transfected cells AQP4-Δ4 is mainly retained in the endoplasmic reticulum and s...

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Bibliographic Details
Main Authors: De Bellis, Manuela, Pisani, Francesco, Mola, Maria Grazia, Basco, Davide, Catalano, Francesco, Nicchia, Grazia Paola, Svelto, Maria, Frigeri, Antonio
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923639/
https://ncbi.nlm.nih.gov/pubmed/24356448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-06-0331
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