Safety and Antiviral Activity of the HCV Entry Inhibitor ITX5061 in Treatment-Naive HCV-Infected Adults: A Randomized, Double-Blind, Phase 1b Study

Background. Hepatitis C virus (HCV) entry involves scavenger receptor B1 (SRB1). In vitro, SRB1 inhibition by ITX5061 impedes HCV replication. Methods. Multicenter study to assess safety/activity of ITX5061 in previously untreated, noncirrhotic, HCV genotype 1 infected adults. Design included sequen...

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Detalhes bibliográficos
Main Authors: Sulkowski, Mark S., Kang, Minhee, Matining, Roy, Wyles, David, Johnson, Victoria A., Morse, Gene D., Amorosa, Valerianna, Bhattacharya, Debika, Coughlin, Kristine, Wong-Staal, Flossie, Glesby, Marshall J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923538/
https://ncbi.nlm.nih.gov/pubmed/24041792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit503
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