A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal

Sustained tumor progression has been attributed to a distinct population of tumor-propagating cells (TPCs). To identify TPCs relevant to lung cancer pathogenesis, we investigated functional heterogeneity in tumor cells isolated from Kras-driven mouse models of non-small cell lung cancer (NSCLC). CD2...

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Detalhes bibliográficos
Main Authors: Zheng, Yanyan, de la Cruz, Cecile C., Sayles, Leanne C., Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D., Bigos, Marty, Xu, Yue, Hoang, Chuong D., Shrager, Joseph, Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Jackson, Erica L., Sweet-Cordero, E. Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923526/
https://ncbi.nlm.nih.gov/pubmed/23845442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.05.021
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