Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.

Stimulation via the T-cell growth factor interleukin 2 (IL-2) leads to tyrosine phosphorylation of Shc, the interaction of Shc with Grb2, and the Ras GTP/GDP exchange factor, mSOS. Shc also coprecipitates with the IL-2 receptor (IL-2R), and therefore, may link IL-2R to Ras activation. We have furthe...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Ravichandran, K S, Igras, V, Shoelson, S E, Fesik, S W, Burakoff, S J
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.11.5275
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