Population Pharmacokinetic Modeling and Dosing Simulations of Nitrogen-Scavenging Compounds: Disposition of Glycerol Phenylbutyrate and Sodium Phenylbutyrate in Adult and Pediatric Patients with Urea Cycle Disorders

Sodium phenylbutyrate and glycerol phenylbutyrate mediate waste nitrogen excretion in the form of urinary phenylacetylglutamine (PAGN) in patients with urea cycle disorders (UCDs); rare genetic disorders characterized by impaired urea synthesis and hyperammonemia. Sodium phenylbutyrate is approved f...

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Main Authors: Monteleone, Jon P. R., Mokhtarani, M., Diaz, G. A., Rhead, W., Lichter-Konecki, U., Berry, S. A., LeMons, C., Dickinson, K., Coakley, D., Lee, B., Scharschmidt, B. F.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923458/
https://ncbi.nlm.nih.gov/pubmed/23775211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.92
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