Suppression of the SOX2 Neural Effector Gene by PRDM1 Promotes Human Germ Cell Fate in Embryonic Stem Cells

The mechanisms of transcriptional regulation underlying human primordial germ cell (PGC) differentiation are largely unknown. The transcriptional repressor Prdm1/Blimp-1 is known to play a critical role in controlling germ cell specification in mice. Here, we show that PRDM1 is expressed in developi...

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Detalhes bibliográficos
Main Authors: Lin, I-Ying, Chiu, Feng-Lan, Yeang, Chen-Hsiang, Chen, Hsin-Fu, Chuang, Ching-Yu, Yang, Shii-Yi, Hou, Pei-Shan, Sintupisut, Nardnisa, Ho, Hong-Nerng, Kuo, Hung-Chih, Lin, Kuo-I
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923219/
https://ncbi.nlm.nih.gov/pubmed/24527393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.12.009
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