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Expression of a recoded nuclear gene inserted into yeast mitochondrial DNA is limited by mRNA-specific translational activation.

Genetic code differences prevent expression of nuclear genes within Saccharomyces cerevisiae mitochondria. To bridge this gap a synthetic gene, ARG8m, designed to specify an arginine biosynthetic enzyme when expressed inside mitochondria, has been inserted into yeast mtDNA in place of the COX3 struc...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Steele, D F, Butler, C A, Fox, T D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39231/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643562/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.11.5253
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