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Clobazam and Its Active Metabolite N-desmethylclobazam Display Significantly Greater Affinities for α(2)- versus α(1)-GABA(A)–Receptor Complexes
Clobazam (CLB), a 1,5-benzodiazepine (BZD), was FDA-approved in October 2011 for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years and older. BZDs exert various CNS effects through allosteric modulation of GABA(A) receptors. The structurally disti...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3922815/ https://ncbi.nlm.nih.gov/pubmed/24533090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088456 |
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