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DNA damage related to increased hydrogen peroxide generation by hypolipidemic drug-induced liver peroxisomes.

Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes, enhance the activity of peroxisome-associated beta-oxidation of fatty acids, and produce hepatocellular carcinomas in the livers of rodents. Because these chemicals themselves are not mutagens and do...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fahl, W E, Lalwani, N D, Watanabe, T, Goel, S K, Reddy, J K
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1984
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392245/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6096860/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.24.7827
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