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DNA damage related to increased hydrogen peroxide generation by hypolipidemic drug-induced liver peroxisomes.
Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes, enhance the activity of peroxisome-associated beta-oxidation of fatty acids, and produce hepatocellular carcinomas in the livers of rodents. Because these chemicals themselves are not mutagens and do...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1984
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392245/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6096860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.24.7827 |
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