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Molecular genetics of addiction and related heritable phenotypes: genome wide association approaches identify “connectivity constellation” and drug target genes with pleiotropic effects

Genome wide association (GWA) can elucidate molecular genetic bases for human individual differences in “complex” phenotypes that include vulnerability to addiction. Here, we review: a) evidence that supports polygenic models with (at least) modest heterogeneity for the genetic architectures of addi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Uhl, George R, Drgon, Tomas, Johnson, Catherine, Li, Chuan-Yun, Contoreggi, Carlo, Hess, Judith, Naiman, Daniel, Liu, Qing-Rong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922196/
https://ncbi.nlm.nih.gov/pubmed/18991966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1196/annals.1441.018
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