Defense against HSV-1 in a murine model is mediated by iNOS and orchestrated by the activation of TLR2 and TLR9 in trigeminal ganglia

BACKGROUND: Herpes simplex 1 (HSV-1) causes various human clinical manifestations, ranging from simple cold sores to encephalitis. Innate immune cells recognize pathogens through Toll-like receptors (TLRs), thus initiating the immune response. Previously, we demonstrated that the immune response aga...

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Bibliographic Details
Main Authors: Zolini, Guilherme Pimenta, Lima, Graciela Kunrath, Lucinda, Natália, Silva, Mariana Almeida, Dias, Marcela França, Pessoa, Natália Lima, Coura, Bruna Pizziolo, Cartelle, Christiane Teixeira, Arantes, Rosa Maria Esteves, Kroon, Erna Geessien, Campos, Marco Antônio
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922087/
https://ncbi.nlm.nih.gov/pubmed/24479442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-11-20
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