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Cervical Cancer: Development of Targeted Therapies Beyond Molecular Pathogenesis
It is well known that human papillomavirus (HPV) is the causative agent of cervical cancer. The integration of HPV genes into the host genome causes the upregulation of E6 and E7 oncogenes. E6 and E7 proteins inactivate and degrade tumor suppressors p53 and retinoblastoma, respectively, leading to m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3921905/ https://ncbi.nlm.nih.gov/pubmed/24533233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13669-013-0068-1 |
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